Surface coating of tungsten needles can significantly affect their ability to adsorb specific biomolecules in microscale biosensing. Surface coatings such as gold or silica can modify the surface chemistry of the tungsten needle, allowing for the selective binding of certain biomolecules. For example, gold-coated tungsten needles have been used for the selective detection of biomolecules such as DNA, proteins, and viruses. The gold coating can be functionalized with specific capture molecules that bind to the target biomolecule, allowing for sensitive and selective detection. Similarly, silica-coated tungsten needles have been used for the detection of biomolecules such as glucose and lactate. The silica coating can be functionalized with enzymes that catalyze the reaction of the biomolecule of interest, allowing for sensitive detection. Therefore, surface coating of tungsten needles is an important consideration in microscale biosensing applications.
