Sodium metatungstate as an inhibitor biochemical mechanism Ecto-NTPDase inhibitor has less selectivity for NTPDase 1 and 2 relative to NTPDase 3 and P2Y12 (the ki values of NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 are 2.58, 3.26, respectively , >10 and 28.8 μM). Cancellation of renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and cerebellar parallel fiber-Purkinje cell (PF) synapses.
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